Pentobarbital will reduce the extent or outcome of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known. pentobarbital will lower the level or impact of isradipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar. pentobarbital will lower the extent or effect of tolterodine by impacting hepatic... https://mcmasteru110kuf0.techionblog.com/profile