Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators from the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have recognized recurrent mutations in genes regulating tumor cell-microenvironment inte... https://thomass753rai1.robhasawiki.com/user